LymphedemaV1, Main, Exploration, bibRecord, 00A205

Protective immunity in human Bancroftian filariasis: inverse relationship between antibodies to microfilarial sheath and circulating filarial antigens.

Identifieur interne : 00A205 ( Main/Exploration ); précédent : 00A204; suivant : 00A206

Protective immunity in human Bancroftian filariasis: inverse relationship between antibodies to microfilarial sheath and circulating filarial antigens.

Auteurs : B. Ravindran [Inde] ; A K Satapathy ; P K Sahoo ; J J Babu Geddam

Source :

Parasite immunology [ 0141-9838 ] ; 2000.

RBID : pubmed:11123755

Descripteurs français

KwdFr :
- Adolescent, Adulte, Animaux, Anticorps antihelminthe (sang), Antigènes d'helminthe (sang), Enfant, Enfant d'âge préscolaire, Facteurs de l'âge, Filarioses (immunologie), Humains, Immunité, Inde (épidémiologie), Sujet âgé, Wuchereria bancrofti (immunologie), Éléphantiasis (immunologie), Études de cohortes.
MESH :
- immunologie : Filarioses, Wuchereria bancrofti, Éléphantiasis.
- sang : Anticorps antihelminthe, Antigènes d'helminthe.
- épidémiologie : Inde.
- Adolescent, Adulte, Animaux, Enfant, Enfant d'âge préscolaire, Facteurs de l'âge, Humains, Immunité, Sujet âgé, Études de cohortes.
Wicri :
- geographic : Inde.

English descriptors

KwdEn :
- Adolescent, Adult, Age Factors, Aged, Animals, Antibodies, Helminth (blood), Antigens, Helminth (blood), Child, Child, Preschool, Cohort Studies, Elephantiasis (immunology), Filariasis (immunology), Humans, Immunity, India (epidemiology), Wuchereria bancrofti (immunology).
MESH :
- chemical , blood : Antibodies, Helminth, Antigens, Helminth.
- geographic , epidemiology : India.
- immunology : Elephantiasis, Filariasis, Wuchereria bancrofti.
- Adolescent, Adult, Age Factors, Aged, Animals, Child, Child, Preschool, Cohort Studies, Humans, Immunity.

Abstract

The existence and the nature of protective immunity in human filariasis continues to be a subject of intense debate. While there is no broad consensus on functional immunity against larval and adult stage parasites, anti-microfilarial immunity has been demonstrated to be mediated by antibodies to the microfilarial sheath. In the present study, circulating filarial antigens (CFA), a marker of active filarial infection in human Bancroftian filariasis, was found to be inversely associated with antibodies to microfilarial sheath in a cohort of 411 subjects representing all categories of filariasis across the clinical spectrum of the disease. Approximately 80% of humans of all age groups (5-65 years) were found to have either CFA or anti-sheath antibodies. The inverse relationship observed between these two parameters was found to be independent of the clinical manifestation; both symptomatic and asymptomatic cases were found to display similar inverse association between CFA and anti-sheath antibodies. The prevalence of anti-sheath antibodies in the paediatric group was found to be very high as compared to adults; 78% of children below the age of 10 years tested positive for anti-sheath antibodies although the mf rate and CFA rate were only 4.5% and 22.7%, respectively, in this age group, indicating that developing larvae or juvenile adult stage parasites could have been the source of antigenic stimulus for induction of antibodies to the microfilarial sheath.

PubMed: 11123755

Affiliations:

Inde

Le document en format XML

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Protective immunity in human Bancroftian filariasis: inverse relationship between antibodies to microfilarial sheath and circulating filarial antigens.

Protective immunity in human Bancroftian filariasis: inverse relationship between antibodies to microfilarial sheath and circulating filarial antigens.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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